30–45 min
6–12 months (top-ups advised)
3–6 weeks (after second session)
1–3 days
Polynucleotides are advanced injectables that stimulate fibroblasts, encouraging collagen and elastin production for visibly healthier, more youthful-looking skin. Ideal for treating under-eye circles, fine lines, rosacea, and skin laxity, this treatment works at a cellular level to calm inflammation, restore tone, and promote long-term skin regeneration.
Polynucleotides are purified DNA fragments that act as bio-stimulators when injected into the skin. By activating fibroblast cells, they support collagen and elastin production, aid tissue regeneration, and provide deep hydration and antioxidant benefits. Suitable for areas such as the under eyes, cheeks, mouth, jawline, and neck, they improve overall skin quality without adding volume.
During treatment, polynucleotides are injected into targeted areas using a fine needle or cannula. These DNA chains stimulate the skin’s own regenerative processes, leading to improved elasticity, tone, and hydration. Treatments are spaced 2–4 weeks apart in a course of 2–3 sessions, with results building gradually over time. Maintenance sessions are recommended every 6–12 months.
Combine with collagen-stimulating or hydration-based treatments to maximise skin rejuvenation across multiple layers.
Gently improves elasticity and firmness without adding volume.
Reduces puffiness, dark circles, and fine lines.
Targets forehead lines, smoker’s lines, and crepey skin on the neck.
Evens out roughness and boosts hydration from within.
Results improve over time and can be maintained with top-ups.
At Lecale Clinic, we combine medical-grade treatments with a welcoming, discreet environment in the heart of Downpatrick. Founded in 2017 by Dr McGreevy, a qualified GP and ENT specialist, our clinic is built on years of surgical and aesthetic experience. Every treatment is underpinned by safety, science, and a deep understanding of natural, confident results.
We recommend a course of 2–3 sessions spaced 2–4 weeks apart, followed by a top-up every 6–12 months.
You may notice early improvements after the second session, with full results developing several weeks later.
Needle injections can leave small blebs or bruises that resolve in a few days. Cannula methods usually involve minimal downtime.
Yes, polynucleotides can be combined with microneedling, skin boosters, or anti-wrinkle injections for enhanced results.
Absolutely. Polynucleotides are anti-inflammatory and well tolerated, even in delicate areas.
